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VITAMIN POWER Natural Health Supplements 
Helping to get and keep you healthy.
 
Issue: #071910 JULY 2010

 Polyphenols in Red Wine  And Green Tea Halt  Prostate Cancer Growth 


 In what could lead to a major advance in the

 treatment of prostate cancer, scientists now

 know exactly why polyphenols in red wine

 and green tea inhibit cancer growth.

This  new discovery, published online in The  FASEB Journal (Federation of American Societies for Experimental Biology - Stanford University Libraries), explains how antioxidants in red wine and green tea produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth. This finding is important because it may lead to the development of drugs that
could stop or slow cancer progression, or improve current treatments.

"Not only does SphK1/S1P signaling pathway play a role in prostate
cancer, but it also plays a role in other cancers, such as colon cancer,
breast cancer, and gastric cancers," reported The FASEB Journal.
"Even if future studies show that drinking red wine and green tea isn't
as effective in humans as we hope, knowing that the compounds in
those drinks disrupts this pathway is an important step toward
developing drugs that hit the same target."

Scientists conducted in vitro experiments which showed that the
inhibition of the sphingosine kinase- 1/sphingosine 1-phosphate
(SphK1/S1P) pathway was essential for green tea and wine
polyphenols to kill prostate cancer cells.
Next, laboratory subjects genetically altered to develop a human prostate cancer tumor were either treated or not treated with green tea and wine polyphenols.

The treated laboratory subjects showed reduced tumor growth as a result of the inhibited SphK1/S1P pathway. To mimic the preventive effects of polyphenols, another
experiment used three groups of laboratory subjects given drinking water, drinking water with a green
tea compound known as EGCg, or drinking water with a different
green tea compound, polyphenon E. Human prostate cancer cells
were implanted in the laboratory subjects and results showed a
dramatic decrease in tumor size in the mice drinking the EGCg
or polyphenon E mixtures.

"The profound impact that the antioxidants in red wine and green tea
have on our bodies is more than anyone would have considered just
25 years ago," the researchers added. "As long as they are taken in
moderation, all signs show that red wine and green tea may be
ranked among the most potent 'health foods' we know.
Source: Federation of American Societies for Experimental Biology publishes The FASEB Journal. Stanford University Libraries
Issue: #072110 JULY 2010

Omega-3 May Also Protect Against Hearing Loss According To New Study

  New Omega-3  Research Sheds New                      Meg-EPA Natural Fish Oil Supplement

  Light On These Nutritional Lipids and

  Oils For Their Beneficial Roles In

  Supporting Cardiovascular Health,

  Cognitive and Mental Function                               

  Increased intakes of omega-3 fatty acids,
  and the fish that provide them, may reduce
the risk of age-related hearing loss, says a new study from the University of Sydney, Australia.

At least two servings of fish per week was associated with a 42 per cent reduction in the risk of hearing loss in over 50 year-olds, compared with people who average less than one serving per week, according to findings published in the American Journal of Clinical Nutrition.

Similar reductions were observed with intakes of long-chain omega-3
fatty acids, with increasing intakes associated with 14 per cent
reductions in the risk of age-related hearing loss (presbycusis).

"Dietary intervention with omega-3 polyunsaturated fatty acids could
prevent or delay the development of age-related hearing loss," wrote
the researchers. Hearing loss is the most common sensory disorder in the United States, affecting more than 36 million people.

Other micro-nutrients have been linked to reducing the risk of age-related hearing loss.
 In 2007 scientists from Wageningen University reported that Folic Acid supplements delayed age-related
hearing loss in the low frequency region in a study of 728 men and women between the ages of 50 and 70
 (Annals of Internal Medicine, Vol. 146, pp. 1-9).

Another study, published earlier this year indicated a role for beta
carotene and vitamins C and E, and the mineral Magnesium in
preventing  both temporary and permanent hearing loss.
The laboratory-controlled study was presented at the Association for Research in Otolaryngology's annual conference in Baltimore
in February 2009.

The University of Sydney researchers analyzed data from 2,956
participants of the Blue Mountains Hearing Study. Dietary intakes
of fish, and the omega-3s they contain, using food-frequency questionnaires.
Results showed an inverse association between total and long-chain
omega-3 intakes and hearing loss, while increasing fish intakes also
indicated a reduction in the risk of presbycusis, said the researchers.
Correlation is not causation, however, and significant further researchis planned, including human intervention trials.

Omega-3  fatty acids, most notably EPA (eicosapentaenoic acid)
and DHA (docosahexaenoic acid), have been linked to a wide-range
of health benefits, including reduced risk of cardiovascular disease (CVD) and certain cancers, good development of a baby during
pregnancy, joint health, and improved behavior and mood.

Source: American Journal of Clinical Nutrition, published online.
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Issue: #061910 JUNE 2010

Resveratrol (from Grape Seed Extract) May Boost Blood Flow in the Brain, According to New Study

     
   Learn more >>>    Grape Seed Extract Plus Green Tea Extract: 90 Capsules 

More Important Findings About the Naturally-Derived Polyphenol from Grape Seed Extract For Cognitive and Mental Function

High doses of resveratrol may improve blood flow in the brain and potentially boost brain health, say results of a new human study from the UK. A single dose of 250 or 500 milligrams of resveratrol was found to boost blood flow in the brain but did not affect cognitive performance, according to new findings published in the American Journal of Clinical Nutrition.

"The results of the current study provide the first indication in humans that resveratrol may be able to modulate cerebral blood flow variables," wrote researchers from the Brain, Performance and Nutrition Research Centre at Northumbria University. "Thus, it seems reasonable to suggest that the potential effects of this molecule on brain function deserve a great deal more research attention with a clear focus on both healthy humans and pathologic groups," they added.

Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and wine consumption.

Interest in the compound exploded in 2003 when a research team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. The research, published in Nature, was greeted with international media attention. Since then studies have linked resveratrol to longer lives. Other studies have reported anti-cancer effects, anti-inflammatory effects, as well as cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer's.

The new randomized, double-blind, placebo-controlled, crossover study, which involved 22 healthy adults, now suggests a role for the compound in brain health. The researchers randomly assigned the participants to receive placebo, or one of two doses of trans- resveratrol (250 or 500 milligrams supplement). Forty-five minutes after the dose, the blood flow and cognitive performance of the participants was measured over a 36 minute period. Results showed that resveratrol produced a dose-dependent increase in cerebral blood flow, but no increase in the placebo group. The researchers also noted an increase in levels of deoxyhemoglobin after both doses of resveratrol, which they said was indicative of increased oxygen extraction and utilisation. No effect on cognitive function was noted, however. "One key issue regarding resveratrol and other polyphenols is that of the low bioavailability of the parent molecule in humans," wrote the researchers. "The results here confirm that orally administered resveratrol can modulate brain function in humans."  "No significant adverse effects have been observed in human studies using as much as 5,000mg daily and animal toxicity studies using order of magnitude greater dosages have failed to produce serious side effects,"  they added .

Source: American Journal of Clinical Nutrition

(Published online)

"Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation"

     Grape Seed Extract Plus Green Tea Extract: 90 Capsules 

Issue: #060210 JUNE  2010

New Research Shows Low Levels of Vitamin B6  May Contribute To Parkinson's Disease Risk.

Supports Previous Evidence About The Important Role
Of B Vitamins For Cognitive and Mental Function

 

Insufficient levels of vitamin B6 may increase the risk of Parkinson's disease by about 50 per cent, reports a new study from researchers in Japan. The study, published in the British Journal of Nutrition, does not prove that low vitamin B6 levels are the cause of Parkinson's disease, but indicates that additional study should focus on whether increased levels of vitamin B6 may reduce the risk of developing the disease.

Although blood levels of Vitamin B12, Folate (Folic Acid), and Vitamin B2 (Riboflavin) were not directly linked to the incidence of Parkinson's disease, these B complex vitamins are recommended for their synergistic action with Vitamin B6..

Parkinson's disease, named after Dr James Parkinson, the London doctor who initially identified it as a particular condition, occurs
when nerve cells are lost in a part of the brain called the substantia nigra.

According to the American Parkinson's Disease Association, over two million Americans currently suffer from the disease.

This is not the first study to link vitamin B6 intake and the risk of the disease. In 2006, researchers from the Erasmus Medical Center
in Rotterdam reported that people who had daily Vitamin B6 intakes
of 230.9 micrograms or more had an associated risk of developing
Parkinson's disease 54 per cent lower than people who had average daily intakes lower than 185.1 micrograms. The study involved 5,289 people over the age of 55 (Neurology, Vol. 67, pp. 315-318).

The specific link between B Vitamin intake and Parkinson's disease is related to homocysteine, an amino acid reported to potentially toxic
to brain cells. The researchers conducted a hospital-based case-control study involving 249 people with Parkinson's disease and 368 people
without any neuro-degenerative condition.

Intakes of the B vitamins was assessed using a validated, self-administered, semi-quantitative, diet questionnaire.
After reviewing the data, no link between folate, vitamin B12
and riboflavin was observed. However, low intakes of B6 were linked to an increased risk of the disease, independent of other factors, concluded the researchers.

There is a need to confirm these links in both additional observational studies and clinical trials.

Source: British Journal of Nutrition
(Published online)
"Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease: a case-control study in Japan"

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This full-spectrum, easy-to-take multiple vitamin-mineral
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Issue: #051410 MAY  2010

New Study From Sweden: Specific Gene That Regulates Hair Growth Identified

                  VITAMIN POWER Health Supplements
Activation of the gene identified as "Lhx2" leads to increased hair growth.

Exciting new findings reported by research team at Umeå University in Sweden in an article in the latest online edition of the scientific journal PLoS Genetics. The findings partly refute earlier research results in the field.

Functionally, hair is important for temperature regulation, physical protection, sensory activity, seasonal camouflage and social interactions. Hair is formed in hair follicles, which are complex mini-organs in the skin that are specialized for this purpose.

All hair follicles are formed during fetal development, then new hair is generated in the hair follicle by continually undergoing phases of recession, rest, and growth throughout life. The length of the hair is determined by the  duration of the growth phase; for example, the growth phase for scalp hair can proceed for a number of years, while the growth phase for eyebrows last a few months.

After the growth phase, hair formation ceases, and the follicle recedes and enters a period of rest. After a period of rest, a new growth period starts, and the old hair is ejected and lost from the body. The reason for this complex regulation of hair growth is not understood, but it has been suggested that it makes it possible to adjust hair growth to the season.

In the present study, the Swedish research team identifies the specific transcription factor Lhx2 as an important regulator of hair formation. The Lhx2 gene is active during the hair follicle's growth phase and is turned off during the resting period.

The scientists have been able to show that Lhx2 is functionally involved in the formation of hair, as the hair follicles in which Lhx2 has been inactivated, cannot produce hair. The activation of the Lhx2 gene in hair follicles has been shown to activate the growth phase and the formation of hair. The Lhx2 is a gene that is important for the regulation of hair growth.

In stark contrast to previously published research findings from other teams of scientists, the research team at Umeå University found that Lhx2 is primarily expressed outside the so-called bulge region of the hair follicle, where the follicle's stem cells are found.

The Umeå researchers have also shown that Lhx2 is necessary for the hair follicle's growth (anagen) phase to proceed and for the hair follicle's structuring. Moreover, transgenic expression of Lhx2 after birth is sufficient to activate the growth phase and stimulate hair growth.

These findings allow for an alternative interpretation of the function of Lhx2 in hair follicles compared with previous results. Lhx2 is expressed periodically, primarily in precursor cells that are distinct from the cells in the bulging region of the follicles. It is a factor that is necessary for hair
to be formed and to grow.

Journal Reference: Törnqvist et al. Cyclic Expression of Lhx2 Regulates Hair Formation. PLoS Genetics, 2010;

Treating Vitamin D Deficiency
With Supplements Significantly Reduces Heart Disease Risk,
New Studies Demonstrate...


Preventing and treating heart
disease in some patients could
be as simple as supplementing
their diet with extra Vitamin D,
according to two new studies
at the Intermountain Medical
Center Heart Institute in
Murray, Utah.


Researchers demonstrated the link between vitamin D deficiency
and increased risk for coronary artery disease. These new studies
show that treating vitamin D deficiency with supplements may help
to prevent or reduce a person's risk for cardiovascular disease and
a host of other chronic conditions.
 
Study findings were presented at the American College of
Cardiology 59th annual scientific session in Atlanta on March 15,
2010. "Vitamin D replacement therapy has long been associated
with reducing the risk of fractures and diseases of the bone,"
reported the researchers "But our findings show that vitamin D
could have far greater implications in the treatment and reduction
of cardiovascular disease and other chronic conditions than we
previously thought."
 
For the first study, researchers followed two groups of patients for
an average of one year each. In the first study group, over 9,400
patients, mostly female, reported low initial vitamin D levels, and
had at least one follow up exam during that time period.

Researchers found that 47 percent of the patients who increased
their levels of vitamin D between the two visits showed a reduced
risk for cardiovascular disease.
 
In the second study, researchers placed over 31,000 patients into
three categories based on their levels of vitamin D. The patients
in each category who increased their vitamin D levels to 43
nanograms per milliliter of blood or higher had lower rates of
death, diabetes, cardiovascular disease, myocardial infarction,
heart failure, high blood pressure, depression, and kidney failure.
Currently, a level of 30 nanograms per milliliter is considered
"normal." and the link between low levels of vitamin D and increased
risk for a variety of diseases is significant.
 
Treatment options are simple, starting with a blood test to determine
a patient's vitamin D level. If low levels are detected, supplements
and / or increased exposure to sunlight may be prescribed.
 
Increasing vitamin D intake by 1000 to 5000 international units (IU)
a day may be appropriate, depending on a patient's health and
genetic risk. The doctors report supplements are the best source
of vitamin D because they are relatively inexpensive. Most
supplements provide an average of 400 IU per capsule or tablet.
 
While exposure to 20-30 minutes of sunlight can provide up to
10,000 IU, the doctors emphasize it is important to use sunscreen
and avoid the hottest parts of the day in order to avoid sunburn and
the harmful UV rays associated with skin cancer.

Story Source: Intermountain Medical Center (2010, March 17).
"Treating vitamin D deficiency significantly reduces heart disease
risk, studies find."
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Issue: #051710 MAY  2010
 
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